Wednesday, October 30, 2019

Learning and Development (HRM) Managing Training Operations in Essay

Learning and Development (HRM) Managing Training Operations in Training Department - Essay Example By employing this kind of method for training, the training department can cut down costs of hiring an external trainer to do so. The coaching/mentoring method that is being used here is one of the most efficient and easiest of imparting training to the employees, while having no loss faced by the usual traffic of work. In this method a trained senior officer is attached to the trainee, this way the trainee can get hold of his own mistakes and learn from the teachings of the trainer. In this case study, we can see that the intended trainee is attached with the senior trainer, who ends up getting those technical courses. This is although a slow method, but it produces better results than other kind of training. Through this kind of training the trainee grasps the ropes of the trade far more easily and as well as realistically because the person is attached to the experts and there can learn very easily as you are getting the training through practitioners themselves. In this case the trainees gain a hand on experience as to what is right and what is wrong, what should be avoided while imparting training and what tactics and techniques to be used to make the training more affective. The best way to learn about anything is to learn through the practical application of the thing and here the trainers get that experience by being attached to a senior trainer, this will help them observe the way they are giving out training and help them in realizing the key points, that should be taken care of while giving the training. This method is a slow method of training personnel, but in this case it is the most suitable method that the company can use. The other types of training methods are case study method, briefing, in basket training, job instructions training and the job rotation. All these training methods are very subjective sort of methods, while coaching and mentoring can prove to be quite helpful as it would be by far the most practical approach to guide the train ers to be trained for the more technical courses. Such practice will also help create a level of equality among the trainers with respect to the choice of courses and the freedom to select any course that they want rather than doing the one that is left for them. This method is also cost effective as the company does not need to hire extra trainers or other equipments that will facilitate the training process. The coaching and mentoring method will prove to be more useful because the trainees will be able to get hold of the subject quite easily. It is mentioned in the case that the trainees are handed over the materials in advance so that they can prepare for the class. They are given three days to prepare and apply their own learning as trainers to look for innovative ideas, The training that is being imparted here is in-house and work-specific, which means that the training is being done to improve the skill sets of the employees and to enhance the level of understanding. Work spe cific training are usually skill up gradation techniques as the trainees here possess skills to impart training the only thing that they lack is the prowess to handle the technical training course which was generally avoided by them. Word count: 597 1.1 How are different learning styles taken into account? According to the case the model that has been applied is the learning style model by David Kolb, the approach that

Monday, October 28, 2019

Disaster in Franklin County Essay Example for Free

Disaster in Franklin County Essay The role of the major public health personnel, including the public health nurse, is to provide the public with accurate information, and to assure the community, as well as ensure the immediate safety and well-being of the members of the community, while being competent compassionate and accessible. The public health director was contacted by the incident commander to attend the incident briefing due to immediate and long term public health impacts. The fire chief gave report concerning how many people were confirmed dead, what time it occurred and what county(s) were affected. He made the public aware if any hazardous materials had been released and where and whether the hazardous materials team had been dispatched. He also notifies the community of areas of flooding, and any impassable roads and the roads that are closed, as well as any power outages, and possible long term problems that may occur from power loss such as water contamination, and food loss due to spoilage. The fire chief also informs the public that the plan for search and rescue has been initiated. The public health staff had previously had National Incident Management System (NIMS) training. The deputy director sets up the incident command center and does the head count of available responders. The most ideal personnel were not totally available; there were an appropriate number to set up section chiefs and command staff. The chain of command that was used in the simulation consisted of the Public Health Team which included the County Public Health Director, Environmental Health Specialists, and Community Health Nurses, as well as Franklin county staff members, mental health, and social workers, which allowed the community health nurse to have resources available that were used to deal with situations that were outside the nurse’s scope of practice included reporting to EOC well treatment hazardous waste removal. Actions taken by the community health nurse when she encountered possible emergency situations during the door-to-door interviews was to Calm and triage families and offer reassurance and instruction on safety. The public health personnel had to deal with multiple problems both during the initial period and after the immediate danger had past. Actions taken by the community health nurse to help the people who were interviewed cope with the situations after the flooding were: to advise them to stay at shelter where there is electricity and food to contact Environmental health specialists for toxic waste To contact Social services to address immediate needs and resources. To arrange for instruction on safe use of generators in English and Spanish. To make arrangement for medications to be delivered the next day. Techniques that were used or could have been used to calm the fears of the people interviewed are to use short and concise statements. Perform active listening and confirm statements by repeating it back to the person being spoken with, use confrontation avoidance, and De-escalation. The other nursing personnel could be prepared to help in responding to a similar emergency with a much larger affected area (e.g., the effect of Hurricane Katrina). Through the development of a well-organized disaster response plan. Public health staff requires National Incident Management System (NIMS) training. Emergency preparedness training should be performed at least every six months. There needs to be a method of communication in case power lines, towers and electricity are not available; have a backup system in place and know where they are located (e.g. include, walkie talkies, Morse code and emailing). Community nurses should have car stock that includes protective gear (PPE) such as N-95 mask, barriers for CPR, gloves, biohazard containers and isolation gowns. Knowledge of the basic steps that are needed to take to ensure patient safety, such as safe evacuation, and early notification will help prevent unnecessary casualties during emergencies (Agency for Healthcare Research and Quality. www.ahrq.gov/prep. Accessed July 21, 2006. References Centers for Public Health Education and Outreach. (n.d.). Retrieved from https://cpheo1.sph.umn.edu/fcs/index.asp Health Care: Public Health Emergency Preparedness. (n.d.). Retrieved from http://www.ahrq.gov/prep

Saturday, October 26, 2019

Use of Disguise in Twelfth Night Essay -- Twelfth Night Essays

Twelfth Night, "there's something in it that is deceivable". Disguise is very important as a theme in the Twelfth Night.   In fact, disguise is a crucial plot to the play.   It is the thread which runs through the play from start to end and holds it all together.   Yet, paradoxically along the way there are many problems, deceptions and illusions, providing a comment on human behavior and creating comedy. Women's parts were played by boy actors in Shakespeare's day, so the audience would have found special sophistication in Viola's part:   a boy dressing up as a woman who, in the play disguises herself as a man. The first example of disguise in the Twelve Night is viola's disguise as Cesario.   It is in fact central to the plot.   I think it is clearly evident that the fluctuation in attitude to the dual role and the situations and tribulations imposed upon the character Viola/Cesario, ends up creating a better understanding of both sexes and thus, allows Viola to have a better understanding of Orsino.   Viola learns that in role of Cesario, she had to be quick on her feet and defend the probing questi... ...sguise feature in the play.   Emotions and intentions are disguised behind an outer appearance, a pretence or an attitude.   Disguise connects the story, the characters and the different scenes in the play.   Without it the Twelfth Night would not be what it is and I doubt whether it would delight audiences around the world time and time again as it does now. "Nothing that is so, is so" Work Cited Shakespeare, William. The Arden Edition of the Works of William Shakespeare: Twelfth Night. Ed. J. M. Lothian and T.W. Craik. UK: Methuen & Co., 1975.

Thursday, October 24, 2019

Urban Legend of Vanishing Hitchhiker in Pakistan Essay -- Urban Legend

The Vanishing Hitchhiker in Pakistan During my search for stories, I met a sophomore, nineteen year old male student who is majoring in Chemistry and Math. His parents are from Muzaffarabad, Pakistan. Currently, he lives in Maryland. His father is a cardiologist and his mother is a housewife. His parents immigrated to the United States in the 1970's. The source says this story is known by almost three quarters of the people living in Pakistan. His uncle initially told him the story when he went back to Pakistan for the first time. The story takes place in the mountainous regions of Pakistan that are fairly remote from civilization. However, other versions take place in a middle of small towns. One day, a man is driving along a road that is often surrounded by repetitive landscape, such as continuous mountains and plains. Upon driving for quite some time, he spots a silhouette of a woman a kilometer down the road. As he gets closer, he realizes that it is a young woman wearing a slender white dress, and from her expression, he deduces that she has lost her way and needs to get home. From a quick glimpse at her face, he realizes that she is very beautiful. Confused, but being the caring gentleman that he is, he offers her a ride back to her home. She meekly nods as she slowly enters the car and sits in the passenger seat. He begins talking to her, and the subject matter often varies in different variations, but the consensus is that it is small talk. From the moment she speaks, he is astonished by her beautiful voice. Before long, the man actually becomes attracted to her. They continue talking as he continues driving. At one point in their conversation, he reaches to the right to get his drink by his sid... ...s of society will not recognize one in an encounter either. This reflects the fear that one cannot distinguish the real world from the supernatural world. Works Cited Bennett, Gillian. The Vanishing Hitchhiker at Forty-Five. Long Beach: Western States Folklore Society, 1998. Brunvand, Jan Harold. The Vanishing Hitchhiker: American Urban Legends & Their Meanings. New York: W. W. Norton, 1981. Littlejohn, Carol. "Urban Legends and Other Scary Stories." Unknown journal.15.2 (1996): 27-31. Okonowicz, Ed. Baltimore Ghosts: History, Mystery, Legends, and Lore. Elkton: Myst and Lace Publishing, 2004. Turetsky, Rita. Ghosts and Evil Spirits. Publication information unknown. Wilson, Michael. "The Point of Horror: The Relationship Between Teenage Popular Horror Fiction and the Oral Repertoire." Children's Literature in Education 31.1 (2000): 31-40.

Wednesday, October 23, 2019

Kaplan Higher Education Essay

1) You have been asked to design a LAN with operation over a distance of about 100m. Compare and contrast twisted pair cable, coaxial cable, fiber-optics, and wireless for this application. You should create a table or flow chart which would facilitate choosing between these options depending on circumstances. The table or flow chart should be submitted as part of your document. You may not submit a separate file Unshielded twisted pair Fiber optic Coaxial cable Medium Length Baseband: 10/100/1000mbps (CAT 3/5/5e/6) EMI Wavelength (nm): 850/1300 RG Type RG58BU/CU RG59/BU Protection: Shielded/Unshielded Max. Attn.(dB/Km): 3.0/0.9 Conductor Type TC CCS Maximum Segment Length(Thicknet) 500m Min. Bandwidth (Mhz*Km): 200/500 Sheath PVC Cost: Relatively inexpensive Velocity Ratio 666 Toxicity: Plenum/Non Plenum 2) Rank the following five media examples in order from highest data transmission speed to lowest data transmission speed: twisted pair, coaxial cable, fiber-optic cable, microwave, and satellite. 3) a) Satellite b) Fiber Optic c) Coaxial cable d) Microwave e) Twisted pair 4) An entrepreneur is interested in establishing her own world-wide satellite radio infrastructure and has requested your help. Describe and justify the infrastructure that you would develop. Be sure to include the number of satellites needed, the orbits employed for those satellites, and the type and frequency of transmission utilized. a) She will need a multiplexed Earth station satellite system. The ground station accepts input from multiple sources and in some fashion interweaves the data streams, either by assigning different frequencies to different signals or by allowing different signals to take turns transmitting. With frequencies about 2-4 GHz 5) A typical signal sequence in a synchronous connection contains a significant amount of information in addition to just the intended message or data. Identify each of the blocks commonly employed and utilize an analogy to sending a physical package to explain what each block does. a) An analogy of this type of connection would be the transmission of a large text document. Before the document is transferred across the synchronous line, it is first broken into blocks of sentences or paragraphs. The blocks are then sent over the communication link to the remote site. With other  transmission modes, the text is organized into long strings of letters (or characters) that make up the words within the sentences and paragraphs. These characters are sent over the communication link one at a time and reassembled at the remote location. 6) For the network that you have chosen to characterize for this class, identify the primary types of media employed. Be sure to include both how the computers individually connect into the network devices as well as how network devices interconnect and how the connection to the Internet is achieved. Briefly explain the purpose in the network of each type of media employed and identify at least one alternative media which could also fulfill this purpose. a) The network that I have chosen for this class is a Peer to peer network. I will have four computers, one printer/copy/fax machine, and they will be connected with an Ethernet cord and through a local area network. This network is designed for a small business office. References Newman, C. (2014, January 10). Help – AIX 7.1 Information Center. Help – AIX 7.1 Information Center. Retrieved , from http://publib.boulder.ibm.com/infocenter/aix/v7r1/index.jsp?topic=%2Fcom.ibm.aix.commadmn%2Fdoc%2Fcommadmndita%2Fasynch_synch.htm synchronous. (2014, March 9). Merriam-Webster. Retrieved , from http://www.merriam-webster.com/dictionary/synchronous Synchronous and Asynchronous Communication Tools – Articles – Resources – ASAE. (n.d.). Synchronous and Asynchronous Communication Tools – Articles – Resources – ASAE. Retrieved , from http://www.asaecenter.org/Resources/articledetail.cfm?itemnumber=13572

Tuesday, October 22, 2019

Morality and Death Penalty Essays

Morality and Death Penalty Essays Morality and Death Penalty Paper Morality and Death Penalty Paper Morality of Capital Punishment Every human life is precious. This is something that has been taught by the Roman Catholic Church for years. Each day one is alive can be seen as a gift from God. As a result of this gift, we hear many people come up with phrases such as â€Å"Live everyday as your last†, or â€Å"Live as if you’ll die tomorrow†. Unfortunately, for some, these phrases can be more than just a saying. They can be facts. The people, for whom this holds truth, tend to be disliked by many and even hated by some. The type of person who faces a simple phrase such as â€Å"Live as if you’ll die tomorrow† as something that is actually the truth, is typically not a person with much freedom. This type of person, like many other in the same situation, fall under one category; a criminal. A criminal is one held under imprisonment for committing a violent or unlawful act. The type of criminal who lives in uncertainty of their own life is left with the fear of execution every day, due to their act of murder on another human being. This idea brings forth the moral argument of Capital Punishment. Capital Punishment is defined as the legally authorized killing of someone as punishment for a crime. The idea of taking a life as a means of punishing someone for murder has been the subject of a long and often heated debate. While many contend that Capital punishment serves the judicial system as a deterrent to crime and as a lawful penalty many others contend that Capital Punishment is both morally and ethically wrong. Capital Punishment has been used by the United States Government for decades. The government has found that the idea of the death penalty as a just way to punish those who have committed murder. Across the United States of America there are 34 states that actively use Capital Punishment. Most notably are Texas, California, Florida, and even smaller states such as Delaware. The other 16 states, for example, New York, have abolished Capital Punishment at some point in their history. Most recently is Illinois, who abolished the death penalty in their state earlier this year. Of those states that continue to use capital punishment, Texas remains the highest enforcer with 477 executions since 1976. This alone is an astonishing number, and it does not include the high execution rate up to the 50’s. In total, the United States of America, as a whole, have executed 1277 criminals. So far to date, there have been 43 executions in 2011. Most prisoners are forced to wait on Death Row prior to their execution for roughly 170 months. Nonetheless, when their day does come, many prisoners are forced to decide in what manner they wish to be killed. There are five methods of execution that consist of: lethal injection, electrocution, firing squad, hanging, and a gas chamber. The most frequently used in the U. S is the lethal injection. The least likely to be used is a firing squad or a gas chamber. A total of 1103 prisoners have been put to death by lethal injection since 1976 (Dieter 1). Overall, Capital Punishment has been held as a viable way to punish those convicted of a serious murder, despite its brutal method. Many find that Capital Punishment is a practical manner to punish those convicted of murder. This belief stems from the idea that Capital Punishment is a deterrent of crime. In other words, many find that the use of the death penalty publicly decreases the average crime rate. Researchers, who believe this, have found that each execution can be associated with 3 fewer murders in the state of which the execution took place. These scientists are stating that with the execution of one, three lives are saved. In addition, researchers have discovered that executions deter the murder of not only whites, but African-Americans as well. Each execution prevents the murder of one white person, 1. 5 African-Americans, and 0. 5 persons of other races. In other terms, one execution saves the life of not only one race of people, but many. Lastly, they have discovered that shorter waits on death row are connected with increased prevention. For each additional 2-year decrease in the death row wait, one murder is deterred (Muhlhausen 1). This means that if a criminal is executed quicker, it is most likely that people will not murder, therefore saving one life. In general, these people have found that one public execution can save up to 18 lives (Muhlhausen 1). It follows that, the execution of one has the potential to save many others. In contrary, many find this factual evidence to be falsified and over interpreted. As an opposition, many scientists have shown how Capital Punishment does not deter crime. For example, it is a known fact that the South has accounted for roughly 80% of the U. S’s executions. On top of this, the South also holds the U. S’s highest crime rate. Clearly, executing it’s prisoners has little affect on other criminals. Researchers have also used those nations without Capital Punishment to prove how it is an ineffective way to decrease crime. For example, Canada’s crime rate has dropped 27% since their abolishment of the death penalty. Scientists have also discovered factual evidence within the United States to demonstrate the ineffectiveness of Capital Punishment (Beadue 1). A clear example of this is shown by the New York Times survey that illustrates that those states without a death penalty have a lower murder rate. Many of these facts can be classified as coincidental, but nonetheless these facts show that the death penalty alone does not deter crime (Fessenden 1). One simple public execution cannot be given the credit for deterring crime based on this evidence. To conclude, public execution can only be coincidental to a decrease or increase in crime rates, proving it as a less effective way to deter crime across America. Whether or not it deters crime can be a miniscule fact to those who find that Capital Punishment as the only just punishment for one who has been convicted of murder and to those who find it completely unjust. Through surveys across the country, those in favor of Capital Punishment have said that only by putting murderers to death can society ensure that convicted killers do not kill again. In addition, many find that the cost to aid an imprisoned killer is unnecessary. Therefore, killing him proves to be cost efficient and easier on the government. On top of this, many find that if you have taken the life of another human being, you yourself do not deserve to live. Although a harsh statement, many refer back to the Old Testament to show the justification through â€Å"An eye for an eye†. Another example is seen through the fact that a prisoner can end up on parole and therefore never is handed the justice he or she deserves for murdering someone. In contrary, many find that Capital Punishment is unjust. For example, many view Capital Punishment as an example of an uncivilized society. In other words, a nation who uses Capital Punishment demonstrates to its citizens an uncivilized way to live (Muhlhausen 1). In addition, many find the death penalty to be a denial of civil liberties. This meaning that the government has no right to simply take a citizens life. Lastly, Capital Punishment is often gone about in an unjust manner. Those executed typically are poor and lack a good attorney, therefore are almost â€Å"set up† for murder. Ethically, Capital Punishment is dreadful. Typically criminal’s who are African American, poor, and in many cases both are executed because of a court appointed attorneys lack of skill. Evidently, they are convicted without a fair trial (National 1). Clearly, there are two sides to the argument that Capital Punishment is justifiable. Through all the facts and fictions of Capital Punishment, ultimately there is one question. This one question asks whether or not Capital Punishment is moral. Morality is defined as a system of ideas of right and wrong conduct. Because everyone’s moral code is different there can be many interpretations of whether or not Capital Punishment is a morally justified behavior. Many find Capital Punishment to be morally correct. This belief is caused by the idea that society has a moral obligation to protect the safety and welfare of its citizens. Many also find that society should support practices that bring about the utmost balance of good as opposed to evil. Clearly, those who believe this credit Capital Punishment as being one of these practices. Finally, those who find it morally correct state that justice itself is moral. In more concrete terms, justice to a convicted murderer is death, and since justice is morally good, this murderer must be murdered them self. It is after the murder of the criminal that â€Å"justice for all† is established. Despite the argument for Capital Punishment being morally right, many find it to be morally wrong. Many people find that capital punishment is morally deplorable on the basis that society has a moral obligation to protect human life, not take it. This means that we are all called upon to protect the sacredness of human life and not to take it away. On top of all this, it has been said that locking a criminal away for life achieves the same goal as Capital Punishment. This goal is to stop the violent acts committed by the criminal. Therefore, taking away a life is nonsensical and not necessary according to those who find Capital Punishment morally incorrect. The death penalty also proves to be morally wrong as it decreases the value of life, according to many. Many state that the death of anyone, even a convicted killer, diminishes us all. Evidently, morally Capital Punishment can be seen as not only wrong, but unacceptable. Ultimately, there are cases given both for the moral correctness of Capital Punishment and the moral wrongfulness (Andre 1). The decision on which one is correct lies in the hands of the individual. After researching Capital Punishment and based on my religious background and beliefs, I have formed my own opinion. In every aspect, especially morally, I find Capital Punishment to be wrong. As a living person, I respect life in every form. I believe that life is a gift from God and not one person is ustified to take that gift away. Growing up and going to church I have discovered that every day is a gift no matter what the circumstances. Whether in prison or living freely, God has granted you another day to experience life. This experience is different for everyone, but meaningful for all. This is simply another reason I find it deplorable to take the life of an individual. The ethics of Capital Puni shment is another aspect that fuels my reasoning against it. It is deeply upsetting to me that simply because of your lack of wealth or your race affect your chance at life. I believe that no matter your stature, you deserve a good attorney and a fair trial, because without a fair trial or good attorney it has been proven you are more likely to lose that trial. Being African American should not lower your chances at survival simply based on America’s court system. For a nation who claims to be almighty and great, I find it astonishing that they continue to hurt those who live there based on race and wealth. Aside from this, I am appalled by America and their lack of sacredness for life. As stated, life is a gift. If America looked at life as something sacred, as it should be, many would come to see the cruelness that comes with Capital Punishment. Lastly, as a Roman Catholic I believe â€Å"In one God, the Father almighty†. By stating this, I state that there is only one God. This one God is the only one who can grant and take away life. It is then that I ask America’s governing system, who gave them the right to play God. I do not believe that anyone has the right to simply take life away from someone. God, and only God, has the right to give and to take a life. Because If I am not mistaken, the United States of America did not grant me or anyone else life, God did. This is why I am astonished at my country’s government’s ability to take away someone’s life. Overall, I find Capital Punishment to be unjust and a moral flaw in America’s punishment system. In conclusion, Capital Punishment is still today, a consequence faced by many criminals. Many states continue to use this form of punishment, as others continue to abolish it. Nonetheless, it is a national moral issue faced by all. The case has been given by both counterparts and leaves many questioning their own belief. Many state how Capital Punishment deters crime, as others state that it has little effect. In addition, it has been said that Capital Punishment is just and lawful, despite the belief of many that it is just the opposite. Thus, I am only left to ask, if the government says it is illegal to take a human life, then why are they able to do so? Andre, Claire, and Manuel Velasquez. Capital Punishment: Our Duty or Our Doom? Santa Clara University Welcome. Saint Clara University. Web. 20 Nov. 2011. scu. edu/ethics/publications/iie/v1n3/capital. tml. Beadue, Huggo. The Case Against the Death Penalty Cons, Anti Death Penalty Arguments. American Civil Liberties Union. American Civil Liberties Union, 2011. Web. 20 Nov. 2011. aclu. org/capital-punishment/case-against-death-penalty. Dieter, Richard. Death Penalty Information Center. 2011. Web. 20 Nov. 2011. deathpenaltyinfo. org. Fessenden, Ford. Deadly Statistics: A Survey Of Crime and Punishment New York Times.   NY Times Advertiseme nt. New York Times, 22 Sept. 2000. Web. 20 Nov. 2011. ytimes. com/2000/09/22/us/deadly-statistics-a-survey-of-crime-and-punishment. html. Muhlhausen, David. The Death Penalty Deters Crime and Saves Lives. Conservative Policy Research and Analysis. Heritage Foundation, 28 Aug. 2007. Web. 20 Nov. 2011. heritage. org/research/testimony/the-death-penalty-deters-crime-and-saves-lives. National Coalition to Abolish Death Penalty. NCADP The National Coalition to Abolish the Death Penalty. 25 Dec. 2008. Web. 20 Nov. 2011. ncadp. org/index. cfm? content=25.

Monday, October 21, 2019

The Differences (and Similarities) Between Dystopian and Post-Apocalyptic Fiction

The Differences (and Similarities) Between Dystopian and Post-Apocalyptic Fiction From The Hunger Games to The Walking Dead, dystopian and post-apocalyptic stories have become massively popular- and their popularity shows no signs of slowing down. In many cases, the line between the two genres is decidedly blurred. However, each has unique characteristics that separate it from the other. Most noticeably, while dystopian fiction often explores social or political struggle, society is still operating and has not yet collapsed (although it might be on the brink). Meanwhile, in apocalyptic fiction, the focus is less on society and more about the characters or a man vs. nature conflict.Lets look at each of these genres in more detail.What is dystopian fictionGenerally, dystopias use contemporary society as a basis for their imagined dystopias, lending an element of social warning in the texts. In this way, authors can use facets of modern society to imagine what a futuristic one might look like- and in a dystopia, that future is most often very dark and troubling.The N etflix original dystopian series Black Mirror is a great example of how this is done, as it shows how things like social media and overuse of technology might be contributing to a dystopian future for humanity. The series, as well as many other dystopian works, shows how technology might soon prove to be more harmful than good (for us as a species, and for civilization in general), and how it could indeed be making us less human- and less humane.Netflixs Black Mirror is a great example of modern dystopian storytellingDystopian literature and worksThe rise in dystopian literature follows the rise in technological innovation. In many ways, it can be seen as a response to (and fear of) the innovation we depend on in our day-to-day lives. It asks questions like: Where will all this lead us? And will social order survive?As a direct and contrasting response to utopian literature, dystopian fiction is most often seen as a genre that began with E.M. Forsters The Machine Stops, a short stor y published in 1909 in The Oxford and Cambridge Review. It was later republished in Forsters The Eternal Moment and Other Stories in 1928. In the story, humanity is forced to live underground and must rely on a large machine to provide for it. In Yevgeny Zamyatins We, the future is one that is governed entirely by logic and reasoning, with characters named D-503 and O-90. George Orwells Nineteen Eighty-Four, shows a society at constant war and controlling its people through propaganda, censorship, and an oppressive police state.Aldous Huxleys Brave New World, written in 1931, is the story of a world in which citizens are drugged, genetically modified and placed into castes based on their intelligence. Anthony Burgess A Clockwork Orange, published in 1962, shows a future, dystopian England that is plagued by youth violence. Margaret Atwoods The Handmaids Tale is a dystopian tale in which the future United States is a totalitarian theocracy and women have no rights.Dystopian fiction h as also become extremely popular among Young Adult (YA) readers, with titles like The Hunger Games by Suzanne Collins, The House of the Scorpion by Nancy Farmer, Divergent and Insurgent by Veronica Roth, The Maze Runner by James Dashner, and Delirium by Lauren Oliver.Some of the common themes and situations seen in dystopian fiction are:Mass povertyA police state or abuse of power by governmentTechnology gone wrongLoss of individualismIneffective or oppressive social institutionsOveruse of technology or citizens harmed/controlled by itPost-apocalyptic fictionKnown as apocalyptic fiction or post-apocalyptic fiction, the genre involves an event in which civilization or society has collapsed- whether from natural or man-made circumstances, alien invasion, zombie infections, nuclear war, etc. Therefore, one of its qualities that differs from dystopian fiction is that in the latter, there is still a society or social order (although it might be unbearable for those caught within it).Phot o by Scott Rodgerson on UnsplashSince apocalyptic fiction involves characters attempting to survive, it is often more focused on characters and their interaction with others. Themes such as sharing limited resources, trusting strangers, and surviving together are the focus. In this way, apocalyptic fiction allows authors to introduce the depths of their characters most basic fears and needs- and ultimately, determine what it means to be human in the first place.Other common themes and situations seen in apocalyptic fiction are:Depletion of resourcesDangerous weather patterns and/or exposure to the elementsRadiation after a nuclear warPandemic sickness (causing extreme loss of life)Loss of technologyNomadic livingGroup dynamics in survival situationsApocalyptic literature and worksMary Shelleys The Last Man, which was published in 1826, is considered to be the first work of apocalyptic fiction. In it, she describes a plague that kills off most of the worlds population as a group move s through Europe to attempt to escape it. Stephen Kings The Stand, published in 1978, follows a small group of survivors as they attempt to survive a man-made superflu.The Walking Dead is a post-apocalyptic comic-book series written by Robert Kirkman, Tony Moore, and Charlie Adlard, about a group of survivors attempting to escape zombies that have become infected with a deadly (and reanimating virus). Richard Mathesons 1954 novel I Am Legend, which was later adapted for film, likewise describes a global pandemic that has turned the worlds population into zombie-like creatures.Emily St. John Mandels Station Eleven, published in 2014, focuses on a nomadic group of actors and musicians known as the Travelling Symphony and shows a world in which a global pandemic has killed off much of the worlds population. James Dashners The Maze Runner trilogy, published between 2009 and 2011, shows a world in which sun flares have scorched the planet, forcing the worlds governments to kill off most of the population to save resources. Most recently, All Systems Down by Sam Boush is an American novel describing a cyber war that brings down Western infrastructure, causing society to collapse in its wake.Cormac McCarthys The Road is perhaps one of the best written post-apocalyptic novels to date. Published in 2006, it has since been awarded the 2007 Pulitzer Prize for Fiction and the James Tait Black Memorial Prize for Fiction. It was also adapted to a film, which was released in 2009 and directed by John Hillcoat.The following quote is one of the reasons McCarthys tale is so poignant:He walked out in the gray light and stood and he saw for a brief moment the absolute truth of the world. The cold relentless circling of the intestate earth. Darkness implacable. The blind dogs of the sun in their running. The crushing black vacuum of the universe. And somewhere two hunted animals trembling like ground-foxes in their cover. Borrowed time and borrowed world and borrowed eyes with whi ch to sorrow it.Cormac McCarthys The RoadWe dont even know the main characters name, but Cormac McCarthy created a masterpiece of post-apocalyptic fiction with The RoadIt is this kind of live-in-the-moment simplicity- without smartphones or television distracting us- that attracts modern audiences to apocalyptic fiction and is perhaps one of its greatest themes.

Sunday, October 20, 2019

Definition and Examples of Sorites in Rhetoric

Definition and Examples of Sorites in Rhetoric In logic, sorites is a  chain of categorical syllogisms or enthymemes in which the intermediate conclusions have been omitted. Plural: sorites. Adjective: soritical. Also known as  chain argument, climbing argument, little-by-little argument, and polysyllogism. In Shakespeares Use of the Arts of Language (1947), Sister Miriam Joseph notes that a sorites normally involves repetition of the last word of each sentence or clause at the beginning of the next, a figure which the rhetoricians called climax or gradation, because it marks the degrees or steps in the argument. Etymology:  From the Greek, heap​Pronunciation:  suh-RITE-eez Examples and Observations Here is an example [of sorites]: All bloodhounds are dogs.All dogs are mammals.No fish are mammals.Therefore, no fish are bloodhounds. The first two premises validly imply the intermediate conclusion All bloodhounds are mammals. If this intermediate conclusion is then treated as a premise and put together with the third premise, the final conclusion follows validly. The sorites is thus composed of two valid categorical syllogisms and is therefore valid. The rule in evaluating a sorites is based on the idea that a chain is only as strong as its weakest link. If any of the component syllogisms in a sorites is invalid, the entire sorites is invalid.(Patrick J. Hurley, A Concise Introduction to Logic, 11th ed. Wadsworth, 2012)   St. Paul uses a causal sorites in the form of a gradatio when he wants to show the interlocking consequences that follow from a falsification of Christs resurrection: Now if Christ be preached that He rose from the dead, how say some among you that there is no resurrection from the dead? But if there be no resurrection from the dead, then is Christ not risen: and if Christ be not risen, then is our teaching vain, and [if our preaching is vain] your faith is also vain (I Cor. 15:12-14).We might unfold this sorites into the following syllogisms: 1. Christ was dead / The dead never rise / Therefore Christ did not rise; 2. That Christ did rise is not true / We preach that Christ is risen / Therefore we preach what is not true. 3. Preaching what is not true is preaching in vain / We preach what is not true / Therefore we preach in vain. 4. Our preaching is vain / Your faith comes from our preaching / Therefore your faith is vain. St. Paul, of course, made his premises hypothetical to show their disastrous consequences and then to contradict them firmly: But in fact Christ has been raised from the dead (I Cor. 15:20).(Jeanne Fahnestock, Rhetorical Figures in Science. Oxford University Press, 1999)   The Sorites Paradox While the sorites conundrum can be presented as a series of puzzling questions it can be, and was, presented as a paradoxical argument having logical structure. The following argument form of the sorites was common: 1 grain of wheat does not make a heap.If 1 grain of wheat does not make a heap then 2 grains of wheat do not.If 2 grains of wheat do not make a heap then 3 grains do not...._____∠´ 10,000 grains of wheat do not make a heap. The argument certainly seems to be valid, employing only modus ponens and cut (enabling the chaining together of each sub-argument involving a single modus ponens inference.) These rules of inference are endorsed by both Stoic logic and modern classical logic, amongst others.Moreover its premises appear true. . . .The difference of one grain would seem to be too small to make any difference to the application of the predicate; it is a difference so negligible as to make no apparent difference to the truth-values of the respective antecedents and consequents. Yet the conclusion seems false.(Dominic Hyde, The Sorites Paradox. Vagueness: A Guide, ed. by Giuseppina Ronzitti. Springer, 2011)​ The Sad Sorites, by Maid Marion The Sorites looked at the PremissWith a tear in his wistful eye,And softly whispered a Major TermTo a Fallacy standing by.O sweet it were to wanderAlong the sad sea sand,With a coyly blushing PredicateClasping thy willing hand!O happy are the Mood and Tense,If such indeed there be,Who thus Per Accidens may roamBeside the briny sea.Where never Connotation comes,Nor Denotation een.Where Enthymemes are things unknown,Dilemmas never seen.Or where the tree of PorphyryBears stately branches high,While far away we dimly seeA Paradox pass by.Perchance a Syllogism comes,In haste we see it flyHither, where peacefully it restsNor fears Dichotomy.Ah! would such joys were mine! AlasEmpiric they must be,Till hand in hand both Mood and TenseAre joined thus lovingly.(The Shotover Papers, Or, Echoes from Oxford, October 31, 1874)

Saturday, October 19, 2019

Personal Statement Example | Topics and Well Written Essays - 500 words - 34

Personal Statement Example Furthermore, during my years in high school, I passed very well in my major subjects and more specifically, anything related to the philosophy of law. On the contrary, I would watch television programmes that were based on the application of law and how the courts of law work. Additionally, I spent a couple of two days a week in my father’s friend’s office who is a solicitor to learn more about law. This was very advantageous to me because I was granted chances to attend magistrate’s courts on numerous occasion. Therefore, apart from my academic prosperity, I believe I am the best candidate to pursue law because I have field experience of the application of the same. In high school, I was the class representative and highly participated in co-curricular activities such as games and sports. I was a basketball player and I enjoyed every bit of the game. During practice sessions, I was given a mandate of being a referee by our school coach because I was quick to administer judgement very fairly. My critical thinking techniques and conflict resolution skills enabled me to be given such responsibilities. I also helped my former classmates to study and improve their GPA in the subjects they were weak at because I saw it as my duty to help them overcome their obstacles. On the other hand, my oral skills are outstanding because I participated in drama and acting, which enabled me to construct accurate and fluent sentences. I was also good at written text and thus my high school career was marvellous. My dream career is being a judge. It is my sincere prayer and hope that given an opportunity to undertake a course in law at the university will mold me into achieving my dreams. I am sure that given the correct guidance and hard work will see me through to achieving all my future plans because I am very gifted at law. It is my belief that my calling was in pursue of law and a great

Friday, October 18, 2019

Ethnographic Study of the Skateboarding Culture Essay

Ethnographic Study of the Skateboarding Culture - Essay Example The purpose of this essay is to provide an ethnographic description of the language, behavior, values and beliefs of the skateboarders in order to understand their cultural orientation as a group. In this ethnographic study, the culture of skateboarding is described through observing skateboarders in action. The findings suggest ideas of concern for safety, acceptance, progression, self-expression of style and energy & drive. Through the observation of cultural artifacts and styles of communication, the culture of competitive skateboarding is described and all the generalizations encompassed in skateboarding discussed. Using the small sample of skateboarders, data will be collected and analyzed in order to draw conclusions about the culture of skateboarding ethnographically. This essay has revealed that skaters are not rebels or social deviants, as they are normally perceived by the society. They are often banned from certain areas because of this perception and this limits their fre edom. The female skateboarders describe it as comfortable, empowering, adventurers and fun. The males also say the same as everyone seems to be happy with skateboarding because of their love for it. The researcher states that skateboarders should not be judged harshly as the case is because they have a good organizational culture. The culture empowers them into being responsible adults because it encourages cooperation and support for each other regardless of the differences based on age, race or sexual orientation.

Nazi Germany Essay Example | Topics and Well Written Essays - 2750 words

Nazi Germany - Essay Example The signing of the treaty by the Weimar Republic head led to a revolution by the Germans. Also, this new government, the Democratic or Weimar Republic was not accepted well among the Germans, partly due to its resistance to democratic rule after being ruled by kings for a long time and their lack of trust in it due to it's supposedly anti-German decisions. Post World War I, Germany's economy was in shambles due to the Treaty of Versailles. They had to pay their debts to their Allies, so they borrowed from other countries and were able to recover soon. Also, the Allies put forth a reparation plan which resulted in a free economy which resulted in the people opposing the government more vehemently. This opposition resulted in the fall of Weimar Republic and the rise of the communist parties and the Nazi party led by Adolf Hitler. By 1933, Germany's economy strengthened and the German army which was not loyal to the government, once again became very strong under Seeckt. There was also a strong nationalist thought rising among them. These nationalist parties gained loyalty from the army and the Nazi party which was striving on these ideals came to absolute power in 1933. Guisepi observes that Hitler's hatred of poverty, his devotion to his German heritage and his loathing of Jews all formed his political perspective or doctrine (2001). Hitler's past, his experiences in life and influences made him the way he was. He developed contempt for the political government because they led to all the unemployment, war defeats, political and economic crisis in the country that once was a major force to reckon. Hitler also believed in racial theories of the times which led him to execute anti-Semitist policies. Under this policy, the Germans belonging to the Aryan or Master race should persecute the Jews supposed to be the Non-Aryan or Slave race. This anti-Semitism was executed very faithfully immediately after Nazi party came into power in July 1933 (Gordeeva, 1998). It is observed that Hitler made very fast moves once he came into power and within six months he invaded Poland. Hitler is observed to be influenced by the political skills of the Mayor of Vienna, who used all possible instruments to gain power. This technique of absolute power has been used by Hitler to propagate his totalitarian, militaristic, anti-Semitic and dictatorial regime known as the Third Reich (Guisepi, 2001). Nazi party's breach of Treaty of Versailles and the Great Depression in the whole world led to World War II. It is called a World War because most of the countries of the world were involved in the war after Nazi regime invaded Poland. It is supposed to be the most costly war, involving the most countries and killings. There was large scale genocide known as Holocaust (Wikipedia contributor, 2009). The Nazi regime in its initiation of war and the Holocaust successfully managed the extreme support from a majority of the Germans. But there have also been incidents of opposition to this regime and its extreme policies from various individuals and groups. Any kind of existing or perceived opposition was brutally suppressed by the army. Hitler used the Alignment Act to implement the policy according to which all institutions and organizations would come under Nazi control which meant that Non-Aryans and German controlled territories would

Thursday, October 17, 2019

The relationship between the ozone hole and the world corporate Research Paper

The relationship between the ozone hole and the world corporate pollution - Research Paper Example The nineteenth century and the earlier half of the twentieth century was a time of relative innocence (some would say ignorance) of how industrial processes would be affecting the environment we live in. People thought that the atmosphere, oceans, and rainforests of the world were limitless and unchanging. It is only during the 1960s and thereafter that serious inquiry into the effects of human activity on the ecology was conducted. Ozone is a molecule comprised of three atoms of oxygen, rather than the usual 2 atoms. It therefore has the symbol O3. The word â€Å"ozone† comes from the Greek word â€Å"ozein† meaning â€Å"smell†, because of its pungent odour. It was discovered in 1839 by Christian Friedrich Schà ¶nbein, when he detected a by-product of electrical discharges. It was only in the early twentieth century, however, when ozone was determined to be found in large quantities in the stratosphere (Reid, 2000). Most popular literature deal with the ozone hole, located over the Antarctic in the stratospheric level. This indicates a thinning of ozone in the place where it does the most good. It became so depleted in certain areas as a reaction to the pollutants released in the air by industrial processes, and in the household by the use of chlorofluorocarbons and other chemical products. Very few, however, know that ozone has been accumulating in a layer closer to the ground than the stratosphere, namely the troposphere. Closer to the earth, ozone is a poisonous substance and where it would touch the earth, it may cause deaths and damage to the lungs. The first relationship depicted above shows the formation of the ozone layer in the stratosphere, its proper location for greatest benefit. The ozone has varying effects on different types of ultraviolet radiation. UV-C, the ultraviolet ray with the shortest wavelength is the type most effectively screened, while UV-A, which has the longest wavelength, is that which passes straight through

The ways of resolving conflicts Assignment Example | Topics and Well Written Essays - 250 words

The ways of resolving conflicts - Assignment Example This research will begin with the statement that if one were in Lee Lattoni’s place, one will deal directly with the conflict by talking with B.J. O’Malley first before making any decision. Since B.J. seems to be the leader of the male group in the cost accounting department, the objective is to convince him to accept the decision so that eventually, he can convince the others in the department. One will tell him about the plan to hire Regina Simpson and the reason why one believes that it will be for the best interest of the department to hire her. One will point out to him that it will make the department more efficient and if that happens, everyone in the department will benefit because management will see its improved performance. One will request him to just be open to the idea and not judge Regina prematurely. One will also talk with Regina to inform her in advance about how she might be treated in the department and the culture that pervades there. She will, howe ver, be assured that she will have one’s 100 percent support. For B.J. O’Malley is the difference in the values, beliefs, and personalities. Whereas Lee and Regina value a college education, B.J. and the rest of the males in the department find it irrelevant. The insecurities of the males in the department are reasons why they do not want Regina to join them. Their male egos are threatened by Regina’s presence, especially her educational background.

Wednesday, October 16, 2019

The relationship between the ozone hole and the world corporate Research Paper

The relationship between the ozone hole and the world corporate pollution - Research Paper Example The nineteenth century and the earlier half of the twentieth century was a time of relative innocence (some would say ignorance) of how industrial processes would be affecting the environment we live in. People thought that the atmosphere, oceans, and rainforests of the world were limitless and unchanging. It is only during the 1960s and thereafter that serious inquiry into the effects of human activity on the ecology was conducted. Ozone is a molecule comprised of three atoms of oxygen, rather than the usual 2 atoms. It therefore has the symbol O3. The word â€Å"ozone† comes from the Greek word â€Å"ozein† meaning â€Å"smell†, because of its pungent odour. It was discovered in 1839 by Christian Friedrich Schà ¶nbein, when he detected a by-product of electrical discharges. It was only in the early twentieth century, however, when ozone was determined to be found in large quantities in the stratosphere (Reid, 2000). Most popular literature deal with the ozone hole, located over the Antarctic in the stratospheric level. This indicates a thinning of ozone in the place where it does the most good. It became so depleted in certain areas as a reaction to the pollutants released in the air by industrial processes, and in the household by the use of chlorofluorocarbons and other chemical products. Very few, however, know that ozone has been accumulating in a layer closer to the ground than the stratosphere, namely the troposphere. Closer to the earth, ozone is a poisonous substance and where it would touch the earth, it may cause deaths and damage to the lungs. The first relationship depicted above shows the formation of the ozone layer in the stratosphere, its proper location for greatest benefit. The ozone has varying effects on different types of ultraviolet radiation. UV-C, the ultraviolet ray with the shortest wavelength is the type most effectively screened, while UV-A, which has the longest wavelength, is that which passes straight through

Tuesday, October 15, 2019

Analytical reading Essay Example | Topics and Well Written Essays - 1500 words

Analytical reading - Essay Example Huang argues that Pomeranz and other scholars who write about the Chinese and European economies do from the point of view of their own countries and not from the point of view of the region in question. This is known as a lack of ethnocentricity in political science. What this means is that the political scientists resort to bias in favor of their own regions and also lack what is known as perceiving the world through the eyes of the inhabitants who are specific to the region in question. This apparent blindness towards the subject area is the lack of ethnocentric bias and this means that the scholars do not judge the subject material from the point of view of the subjects themselves. Huang is even handed when he points out studies by Chinese scholars fare no better when it comes to discourse on the European region and hence it is by no means settled that there is anything specific about claims made by both European and Chinese scholars. Hence, the criticism that Huang levels at Pomeranz is borne out by the lack of objectivity in Pomeranz’s analysis about the Chinese economy in the 18th century. Huang and Pomeranz contrast the differing ways in which the Chinese and European peasants went about their occupations by listing the differences that range from simple dietary practices to differences in clothing and other facets of agrarian life. Pomeranz quotes extensively from the data on the food habits of the peasants that include their calorie intake and other parameters that proved the premise that the Chinese were no worse when it came to food intake than their European counterparts. He further compares the non-grain intake with the consumption of meat and comes to the premise that the Chinese fared badly on this count due to the fact that they were pastoral in nature as compared to the meat eating Europeans. Whereas Huang

Business Systems Hoosier Burger Essay Example for Free

Business Systems Hoosier Burger Essay Improving Hoosier Burger Bob and Thelma Mellankamp wanted to open their own business. They came across Myrtle’s Family Restaurant and saw a sign that said it was for sale. Bob and Thelma bought the restaurant and their own restaurant was brought to life Hoosier Burger Restaurant. The idea was one that everyone dreams of owning their own business but do not understand all the behind the scenes projects that make a business successful. Yes, they have been in business for over 30 years but even they understand that their dream needs some improvement to continue in the market they are in. Bob and Thelma have discussed the idea of a computer system but do not know where to start so Bob wants to bring in a consultant to address some of their weak areas and make suggestions to improve Hoosier Burger. They inform the consultant on how business is ran. This restaurant is behind the curve when it comes to technology. They still do paper trail on every aspect of the restaurant from deliveries, inventories, and point of sale (Valacich, George, Hoffer, 2009). Even though paper was what many companies started out with, it is no longer an approved way to do business. Paper allows too many human errors to come into play where as an electronic record keeping system eliminates a majority of these errors but as with any data†¦you get out of it what you put into it. All this means that if you put inaccurate data into the system then the data you get from the system will also be inaccurate. Hoosier Burger has learned this lesson oh too well. Especially, since they did not order enough vanilla ice cream to cover their own special so they had to run to the grocery store to try to get enough for the sales they were doing on the special (Valacich et al., 2009). Bob and Thelma agreed that it would be  valuable to purchase an information system to assist them in the areas of inventory management, marketing, customer service, food preparation, and point of sale (Valacich et al.). Now that it has been decided on what needs to be addressed with thi s new information system. The systems development life cycle (SDLC) begins (Valacich et al., 2009). The four main steps of this process are (1) planning and selection, (2) analysis, (3) design, and (4) implementation and operation. The first phase is to plan the system out and then select the appropriate system for job. This situation a good point of sale system would give this company the system they need for daily operations and growth. A good POS covers all aspects of the restaurant from the dining area to the kitchen and even the storage areas. With any system, you have subsystems that are called components. Components by themselves do not make a system but when put together they make a complete system. In the case of Hoosier Burger one of the components of the system would be an inventory log or database. This subsystem would track usages and deliveries to ensure that stocks are maintain at the properly level for daily operation of the business. The project development team that Hoosier Burger selected w as based on the weaknesses of the organization. The focus of the new system will be on ways to improve inventory management, customer service, and management reporting. Any one of these weaknesses could cripple the organization. The team needs to get as much information as possible to ensure that they are building the correct system for this organization. I would use the interview process to get as much information from the staff as possible and I would use questionnaire to customer input. Also, I would gather as many reports and logs that I could for supporting documentation but with the current processes. This type of information may not be readily available or available at all. After gathering this information, the process of developing a system to correct their weaknesses begins. You would also want to find out if the company has any upgrades planned so that you could incorporate that into the system. In this case, they want to expand to delivery services and a drive through operation. These expansions do not require a lot of upgrades to the building so these will go into effect immediately to increase revenue for the company. The diagram figure 1 shows the flow of information for the new system. Fig 1. As you can see from figure, the information system that need is robust in nature but simple. The system analyst now needs to break down the different entities the company needs to store information about. These entities have particular characteristics that require information to be stored. There are rules used when attempting to place an identifier for each entity. The diagram will show the changes and specify the component’s needed for each relationship. In the text, an entity is a person, object, place, concept, or event in the user environment of which an organization wants to store data(Valacich, George, Hoffer, 2009). Person entities are usually your employees but can be your customer. Place entities are basically the location i.e. states, regions, countries. Object entities include the machines you use, buildings your work out of, products you produce, and vehicles. Event entities can be considered sales, renewals, registrations. Concept entities include courses, accounts, or work centers. Hoosier Burger needs the ability to store information about their individual entities. The main entity is the customer that frequents the restaurant on a regular basis. They also need to store information about what products the customer is purchasing. Hoosier Burger also needs the ability to store information about the company itself and place entities which are the businesses that order meals from the company. We will now discuss attributes. Attributes according to the text are named properties or characteristics of entities that are of interest to the organization(Valacich et al., 2009). The following attributes should be used for the customer: customer name, customer address, customer phone number, customer’s number of orders, and customer specific orders. These attributes can also be assigned to the business entity by switching out customer with business. Attributes can also be assigned to the end product such as ingredients, price, and amount sold. Identifying the entities require assigning unique identifying  characteristics for the entity type. For example when dealing the with customer entity, you would use an identifier that is easy to use i.e. Customer ID, Customer Name, Customer Address, and Customer Phone. The key when dealing with identifying items is making it user friendly. Once all of these have been put into place, the system analyst now needs to build three working solutions to this company’s weaknesses. The three solutions as discussed in the text are low, medium, and high level. The difference in the three levels usually equates to cost but it also includes how much effort the user has to put into the system and the type of technology used. Time is money and if your employees are having to spend more time with the system than the customer then Hoosier Burger will lose money. All of these factors come into play when developing a system for an organization. The key to success of Hoosier Burger and the project development team is communication and cooperation. The more time these two entities communicate with each the easier it will be for the project team to address the needs of the customer and customer addresses the needs of the project team. It is a two way street. In the end, the job of the system analyst is to develop a system that addresses the wants and needs of the customer while maintaining within the budget. You do not want to sell the customer a â€Å"Corvette† when a â€Å"Camaro† would have done what is needed. Reference Valacich, J. S., George, J. F., Hoffer, J. A. (2009). Essentials of Systems Analysis and Design (4th ed.). Upper Saddle River, NJ: Prentice Hall.

Monday, October 14, 2019

Regulation of Human Skin Pigmentation

Regulation of Human Skin Pigmentation Introduction In the human body, the skin is the largest organ, with it being a complicated epithelial and mesenchymal tissue. It consists of an epidermis which is multilayered as well as structures such as sebaceous and sweat glands, hair follicles, a dermis consisting of elastic and collagen fibres. There is also a layer of subcutaneous fat. There has been a discovery of over 1000 disease entities involved with the skin such as eczema, psoriasis, melanoma and urticaria. Around 15% of a human adults total body weight is accounted for by the skin with a surface area of approximately 2m2. The skin consists of three layers; the epidermis, the dermis and the hypodermis. The outer layer of the skin is known as the epidermis, which is a stratified squamous epithelium , where 95% of its cells are keratinocytes. The remaining cells in the epidermis are the melanocytes, merkel and langerhans cells. The role of the epidermis is to provide a defence barrier against environments of an inhospitable nature. The epidermis can be divided into four layers, in order from outer layer to deepest layer; stratum corneum (the cornified layer), stratum lucidum (the clear/translucent layer), stratum granulosum (the granular layer), stratum spinosum (the spinous layer) and the stratum basale (the basal layer) . There is a single layer of keratinocytes in the basal layer, where daughter cells can be produced by them to terminal differentiation via proliferation, resulting in the forming of the cornified layer , which can take around 40 days, however this can be shorter in various diseases, such psoriasis. About ten layers of corneocytes that are flattened make up the cornified layer . From the neural crest, dendritic cells can be derived which are known as melanocytes, which are also found in the basal layer. Melanosomes, which are subcellular organelles, transport melanin, which are synthesised by melanocytes, to the neighbouring basal keratinocytes. In order to prevent harm to the nuclei of the basal keratinocytes from ultraviolet radiation, a melanin cap is formed by the melanosomes. Melanosome size and number, as well as melanins nature determine skin colour or pigmentation. Langerhans cells are derived from the bone marrow and are antigen presenting dendritic cells founds in the epidermis. Sensory information is transmitted from the skin to the sensory nerves by merkel cells found in the epidermis . The dermis is the layer beneath the epidermis, and its thickness depends on the area of the body. For example, on the eyelid, the dermis is thin, whilst the dermis is thick on a persons back. The dermis consists of two layers; the papillary dermis and the reticular dermis. The papillary dermis is in contact with the basement membrane zone, which provides adhesion between the epidermis and dermis, where skin blistering can occur due to defects. Blood vessels as well as sensory nerve endings are richly supplied to the papillary dermis. The reticular dermis is in contact with the hypodermis and is the main component of the dermis. Interstitial components, such as elastic and collagen fibres, and cellular components, such as fibroblasts and plasma and mast cells, are what make up the composition of the dermis. Collagen accounts for around 70% of the dermis dry weight , where types I and III are predominant. The predominant cell type, however, is fibroblasts in the dermis, which are derived from the mesenchyme. The hypodermis is the deepest layer of the skin consisting of lipocytes. The function of the hypodermis is to connect the skin to the bone and muscle, thus supplying the bone with nerves and blood vessels. The arrangement of these is in fat lobules, where the fibrous septae separates one from another. The connection between the dermis and the hypodermis is strengthened by fibre bundles originally from the dermis. Around 80% of the entire body fat is found within the hypodermis in those individuals who are not obese . As very briefly mentioned previously, melanocytes function is dependent upon for pigmentation. These cells from melanoblasts during embryological development. Each basal melanocyte is connected functionally to the dermal fibroblasts as well as to the basal keratinocytes. These three cell types interact and communicate with each other in order to regulate the skins phenotype and function through the secreted factors and receptors in addition to cell to cell contact . Stem cell keratinocytes and basal melanocytes has a slow proliferation rate in normal circumstances, however the upper basal keratinocytes have a much rapid proliferation rate, which carries them towards the skins surface alongside the ingested melanin thus forming a barrier. Therefore the skins colour is not personified by only the melanin found in melanocytes, but also in a conjunction with pigment found in the superficial layers of the skin . Currently, pigmentation is known to be regulated in a direct or indirect fashion by over 125 different genes, with this number potentially rising 150-200 in less than another 100 years. Out of them genes, the ones whose function is understood, a lot of them affect processes that are involved in development which are critical for melanoblasts. Some genes regulate melanocytes differentiation and survival whilst others control processes affecting pigmentation. Melanosomes functions or biogenesis is affected by more than 25 of the genes. Some critical enzymes involved in the control of pigmentation include tyrosinase, tyrosinase related protein 1 (TRP-1) and DCT (DOPAchrometautomerase). If these enzymes are mutated, melanins which are synthesis could be affected in terms of their quantity and quality. Some critical structural proteins required for the melanosomes to mature structurally include Pmel17 and MART1. Mutations in proteins that are involved in the sorting of melanosome proteins can result inherited disorders of hypopigmentary nature . This critical appraisal will look at in further detail the different types of pigmentation, constitutive and facultative, and how they are regulated, including the roles of MC-1R, cyclic AMP (cAMP) pathway Agouti Signalling Protein, MITF and ultraviolet radiation. Also covered in this piece of work is CRHs and ÃŽÂ ²-endorphins roles in regulation of human skin pigmentation. Melanin Within the melanosomes, melanins are synthesises via the previously mentioned enzymes. The reaction which limits the melanogenesis rate becomes catalysed by tyrosinase, as is tyrosinases hydroxylation resulting in 3,4-dihydroxyphenylalanine (DOPA), along with DOPA oxidising into DOPAquinone. The oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) take place in mice due to TRP-1, however this same activity doesnt take place in humans. DOPAchrome is isomerised into DHICA by DCT. In human, there is productions of two types of melanin, eumelanin which is black or brown and pheomelanin which is yellow or red. Tyrosinase is essential for the synthesis of both types of melanin, whilst TRP1 and DCT more for the synthesis of eumelanin . With regards to skin pigmentation, there are two types; Constitutive pigmentation and Facultative pigmentation. Regulation of Constitutive Pigmentation Depending upon the racial and ethnic background of the person, the colour of human skin varies from extremely light to extremely dark. Several major chaperones, melanin, oxyhaemoglobin and deoxyhaemoglobin and carotenoids determine the colour of human skin. In 1954, the first observation was made with regards to the pigmentary system of the skin by Szabo when an immunohistochemical technique was used to test tyrosinases enzymatic activity via staining of tissues , where Caucasian skin was examined at first followed by other colours of skin. Along with various other studies as well as Szabos it was shown that in different human skin types had similar melanocytes densities as well as distribution in similar body areas. They also found that there is less melanin content in lighter skin, with melanosomes which are pigmented poorly being clustered above the nuclei within keratinocytes. There is more melanin present in darker skin, with the distribution of melanosomes that are pigmented heavily being individual in keratinocytes rather than clustered, which increases light absorption. The density of melanocytes is different in distinct parts of the body. For example, the skin on an individuals palms or soles is lighter in comparison to others parts of the body. Environmental factors can affect the density of constitutive melanocytes in the skin, including ultraviolet radiation (UVR), where the density can be increase by 3 or 4 times of the norm. Another environmental factor that can increase the density are toxic compounds, for example hydroquinone, resulting in the destruction of melanocytes. In increase of decreased melanocyte densities, pigmentary disorders which are inherited can result, for example freckles or vitiligo respectively . Due to Bcl2s high expression, epidermal keratinocytes are resistant to apoptosis as they have a slow proliferation rate in normal circumstances. It has been shown that the palms and soles dermis have a high level of Dickkopf-1 (DKK1) secretion which causes the Wnt/ÃŽÂ ²-catenin signalling pathway to become inhibited via the suppression of the growth function of melanocytes, thus inhibiting the melanogenic pathway. This can have effects on some transcriptional regulators, for example microphthalmia transcription factor (MITF), to some downstream melanogenic proteins. Epidermal Keratinocytes also become affected by DKK1 as melanin uptake is diminished, resulting in a skin phenotype which is a lot thicker with less pigmentation . Melanocortin 1 Receptor (MC-1R), which is domain receptor of seven transmembranes which binds to pro-opiomelanocortin peptides due to it being coupled with ÃŽÂ ±s G-protein , is a major skin pigment phenotype determinant. It regulated the quality and quantity of melanin production. Two agonists regulate MC-1R function, which are ÃŽÂ ± melanocyte stimulating hormone (ÃŽÂ ±-MSH) and adrenocorticotropic hormone (ACTH). An antagonist called Agouti signalling protein (ASP) also regulates MC-1R function. When ÃŽÂ ±-MSH or ACTH activate MC-1R, melanogenic cascade expression is stimulated, resulting in stimulation of eumelanin synthesis. This can be reversed by ASP, resulting in stimulation of pheomelanin production. MC-1R gene expression can be upregulated by ÃŽÂ ±-MSH and ACTH, which act in a positive feedback loop . Melanogenesis Melanogenesis can be defined as the biosynthetic pathway of melanin in living cells, which is a complex process with multiple steps which involves substrates, specific enzymes already mentioned and various cofactors commencing with phenylalanine and/or tyrosinase resulting in melanin deposition on the melanosomes protein matrix. The understanding of melanogenesis was greatly increased in the 1950s onwards by Fitzpatrick et al . During the cycle of hair growth in Agouti mice, melanogensis regulation occurs quantitatively as well as qualitatively. Pheomelanins are produced instead of eumelanins in the anagen phase, a switch incurred by the melanocytes in the hair follicles, causing a yellow band on top of a brown background. The regulation of this switch involves extension and agouti loci products that encode MC-1R and ASP respectively. When a ligand binds to MC-1R it activates, resulting in activation of adenylyl cyclase by the ÃŽÂ ±s G-protein, causing an increase in the intracellular cAMP significantly. If the extension locus incurs any mutations, the MC-1R reception will become non functional, therefore adenylate cyclase will remain inactive in ÃŽÂ ±-MSH presence, meaning mice will have a yellow coat colour. The MC-1R receptor is bound by ASP, which results in the ÃŽÂ ±-MSH effects being antagonised, which includes the adenylate cyclase activation caused by the ÃŽÂ ±-MSH . There is lots of evidence which shows that ÃŽÂ ±-MSH, ACTH and cAMP have key roles in skin pigmentation regulation in humans. For example, ÃŽÂ ±-MSH hypersecretrion has been reported to cause skin hyperpigmentation. Patients with severe obesity and hair pigmentation which is red have been shown to have pro opiomelanocortin gene mutations . In human melanocytes that have been cultured, dendricity and melanogenesis are upregulated by the pro opiomelanocortin peptides. Pharmalogical cAMP can also mimic these effects. All of this clearly suggests that ÃŽÂ ±-MSH, ACTH and cAMP have a vital role in melanogenesis regulation. Role of cAMP It is suggested that cAMP has a pivotal role in melanogenic enzymes activity / expression regulation. This is because the enzyme activity of melanogenesis is diminished much more than TRP-1 and DCT. The melanogenic effects of the pro opiomelanocortin peptides seem to be mediated via the cAMP pathway upregulation through the activation of MC-1R as well as adenylate cyclase. Within the cell, cAMP binds to protein kinase A (PKA), enabling activation of the catalytic subunit. PKA phosphorylates its substrates, then translocating to the nucleus, phosphorylating cAMP responsive element binding protein (CREB) transcription factors family. Specific genes have their expression activated by this family of proteins, which contains consensus cAMP responsive element (CRE) sequences within their promoters. CREB-binding protein is also phosphorylated by PKA, where PKA dependent gene expression is required in order for the interaction with the family of CREB proteins . MITF, which is a helix loop helix transcription factor has been shown to be encoded by the mi locus. This is due to mice which have the mi mutation have a coat colour which is diluted, have white spots, or entire pigmentation loss. They can also have a microphthalmic phenotype caused by ocular development defects. Within melanocytes, mast cells, pigment cells in the retina and osteoclasts, MITF has been found to be expressed. Also, the lack of melanocytes seems to be the cause of the defective pigmentation in mi mice. It has been established that in the development and survival of melanocytes, MITF plays a key role, which is confirmed by the cloning of the MITF homologue within humans. Patients who have type II Waardenburg syndrome have been known to have mutations in MITF present, where there is defective pigmentation in the skin, hair and eyes, as well as hearing alterations . It was shown by Bertolotto et al that there is some sort of connection between the cAMP pathway with MITF. In normal melanocytes and B16 melanoma cells, MITF expression was shown to be increased by cAMP. Tyrosinase expression stimulation that is induced by cAMP requires MITF as shown by a MITF missing the transactivation domain by a dominant negative mutation . PKA becomes activated by cAMP. PKA then goes on to phosphorylate and activate CREB. CREB binds to CRE after it is activated. The CRE is in the microphthalmia promoter, which upregulates its transcription. Microphthalmia expression is therefore increased, which leads to amplified binding of microphthalmia to the M box motif found in the tyrosinase promoter. Tyrosinase expression is increased, as is the upregulation of the synthesis of melanin. Agouti Signalling Protein In cultured human melanocytes, eumelanin synthesis and the activity of tyrosinase is inhibited by ASP. TRP-1 and the expression of tyrosinase is also reduced by ASP. Because of tyrosinases slightest inhibition of activity as well as to the near loss of the expression of TRP-1 and DCT, ASP decreases eumelanin synthesis. It has been found that genes were downregulated by ASP founds in tyrosinase and DCT, as well as upregulated genes which have some association with a basic helix loop helix transcription factor (ITF2). This shows that ITF2 may have a role in melanogenesis regulation, particularly in the previously mentioned switch of eumelanin to pheomelanin. Regulation of Facultative Pigmentation Physiological regulation that causes an increase in skin colour can be defined as facultative skin pigmentation. There are lots of factors that regulated facultative skin colour, including ultraviolet (UV) which is also known as the tanning reaction which occurs in fish as well as humans. The skins response to UV radiation is kinetically complex causing tanning of the skin over a period of several weeks . The effects of UVR can be divided into acute and chronic effects. The acute effects include erythema (sunburn), tanning and immunosuppression. The skins visible pigmentation is added to by UV causing erythema of the skin itself. There are three different stages of tanning, two of which occur rapidly, immediate and persistent tanning, and one that takes time in order for it to develop, delayed tanning. Immunosuppression can result in a decreased number and function of antigen presenting langerhans cells, as well morphological changes. The chronic effects of UVR include photoaging and photocarcinogenesis. In photoaging, wrinkles and freckles start to appear on the skin, where there is a leather type appearance. Photocarcinogenesis can be caused due to the indirect damage of DNA by reactive oxygen species generation. There are three types of UVR: UVA which is 320 400nm long. Its the longest wave from all the types of UVR and can penetrate deeply into the dermis. UBV is 280 320nm long. It can penetrate the epidermis and is 100 fold more energetic and mutagenic. UVC is 200 280nm long but does not reach the surface of Earth. Immediate Persistent Tanning The reaction of immediate tanning can occur almost instantaneously, within a few minutes after being exposed to UV, where it still persists several hours later. Persistent tanning is a separate second stage of the tanning reaction whereupon it occurs within a few hours after being exposed to UV, with it still being persistent several days later. Melanin and/or melanogenic precursors oxidation and polymerisation is thought to be behind both immediate and persistent tanning. The responses of both these types of tanning are greater to UVA than to UVB. Immediate tanning has a colour of gray to black whilst persistent tanning appears brown.It has been shown that one week after being exposed to UV, there is very little production of more melanin . Reported in 1986 was that immediate tanning can be educed by UVA in epidermal sheets. Honigsmanns results suggested that existing melanin or melanin precursors chemical oxidation is reflected upon by immediate tanning rather than pigment granules physiological movement. Reactive oxygen species are able to cause the oxidation of tyrosine as well as DOPA to melanin which occurs in immediate tanning. Also, pigmentations UVA induction is dependent upon melanin which is soluble and there are two different types of melanin absorption which are involved in UVA photoxidation. Delayed Tanning The reaction of delayed tanning has a developmental time of more than several days. Skin tanning appears to peak one week after being exposed to UV, after which tanning appears to diminish for the next ten weeks, but doesnt return to the constitutive level after that time. Within the same time frame, Asian skin pigmentation increase is relatively small. Therefore there is a higher level of hyperplasia in skin that contains smaller levels of constitutive pigment, playing somewhat of a protective role in the response to UV than did the increased pigmentation the skin types that are lighter. Skin pigmentation increase over a long term caused by UV are due to lots of physiological facts being regulated by UV, affecting the growth and / or differentiation of melanocytes. Pigmentation is also stimulated by DNA damage caused by UV exposure . The levels of eumelanin and pheomelanin slowly increase together after being exposed to UV on human skin. This shows that by UV, they are not regulated separately. In various ethnic origins skin pigmentation, there are around two fold differences in melanins chemical content and the melanosomes distribution and size of the particle are important to the visible colour of skin. In comparison with skin which is protected to skin which is constantly radiated with UV, there is only less than a two-fold increase again. All of this shows that aside from the quantity of melanin, other factors are necessary for skin pigmentation. An increase in their expression of ÃŽÂ ±-MSH and ACTH is a response by epidermal keratinocytes and melanocytes to UV exposure. This MC-1Rs function and expression to become upregulated, increasing the response of melanocytes to melanocortins. The weakly functioning MC-1R variants can be located in people with fair skin with red hair who have more pheomelanin with an inability to get a tan. The expression of Endothelin-1 by keratinocytes is enhanced by UV, thus enhancing MC-1Rs expression also, but endothelin-1 works via its own receptor on the melanocytes. The secretion of interleukin-1 by keratinocytes is also caused by UV, stimulating endothelin-1, ÃŽÂ ±-MSH and ACTH secretion by keratinocytes. In keratinocytes, p53s stimulation by the exposure to UV causes increased POMC gene expression resulting in an increase in ÃŽÂ ±-MSH secretion as well as MC-1R function stimulation in the neighbouring melanocytes . ÃŽÂ ²-endorphin/ÂÂ µ-opiate receptor It was reported for the first time by Kauser et al that ÃŽÂ ²-endorphin and the ÂÂ µ-opiate receptor system is expressed in epidermal melanocytes, theyre associated closely with melanosomes, and that in melanocyte biology regulation, this system is active due to its pigmentation, dendricity and proliferation upregulating ability. In the epidermal melanocytes and keratinocytes, the presence of both aforementioned ligand and receptor gives a platform for both autocrine and paracrine mechanisms for the regulation of melanocyte behaviour. ÃŽÂ ²-endorphin and ÃŽÂ ²-lipotropic levels are raised being exposed to UVR , further suggesting that ÃŽÂ ²-endorphin has a role in epidermal melanocytes. Kauser et al also showed that ÃŽÂ ²-endorphin that has been supplied exogenously can cause an increase in melanogenesis and proliferation in epidermal melanocyte cultures. ÃŽÂ ²-endorphin also has an association with melanosomes suggesting that melanogenesis might be regulated l ocally in the secretory granule. Corticotropin Releasing Hormone It has been established that Corticotropin Releasing Hormone (CRH) does have some sort of role in pigmentation. MC-1R action as well as the ÂÂ µ-opiate receptor moderates melanocytes behaviour in hair follicles where there is complete expression of the pro opiomelanocortin system within the pigmentary unit. The expression of CRH is low is different melanogenic zones, whilst there is differentiated distribution of melanocytes in the same area. CRH Receptor 1 seems to be more important in follicular melanocytes for the stimulation of melanogenesis, proliferation and dendricity. However, the role of CRH is in skin pigmentation is not 100% full established, and is an area that definitely required further research in order to gain some clarification. Aging As people get older, pigmentation continues to increase until adolescence or adulthood. Once theyve reached this point, pigmented lesions often begin to appear, and the hair starts to turn gray. It was found in 1979 that the quantity of melanocytes was decreased by about 10% with each decade the age went up by. This was confirmed by two other researches , where one was carried out on darker skin also. Another study compared very fair skin with Caucasian skin, finding that melanocyte density was greatly enhanced following continuous exposure to sunlight in the darker skin, however langerhans cell densities were decreased in the same time frame in both skin types after being exposed to UV.. It was proposed by Stierner et al that being exposed to UV might have some role in the development of melanoma in both exposed and protected skin, as well as being exposed to aberrant UV profoundly can be a lot more harmful than normal exposure , which has since been confirmed by various other studi es . Disruption of Regulation From time to time, different types of pigmentary disorders can occur due to disturbance of the normal regulation of skin pigmentation. Tyrosine function regulation lays importance on intracellular pH as catalytic functions are affected by the intramelanosomal pH as well as melanosomal protein delivery requiring the sorting pathway to have the right pH gradient. It is also considered that pigment production is regulating in some part by intracellular pH in different types of skin depending upon the racial or ethnic origin . Every single form of albinism is caused by tyrosine dysfunction or other types of melanogenic proteins, which can cause skin pigmentation to be blemished. Another pigmentary disorder is Hermansky Pudlak syndrome. This disorder have pleiotropic clinical effects . Pigmentary disorders which are caused by the acquiring of melanin involve the skin becoming lighter or darker. Skin colour which reduced is normally caused from epidermal melanin content declining. The skin may become darker due to an extremely large number of melanin being produced due to there being a an enhanced quantity of melanocytes, however it can also be due to melanin distribution becoming abnormal. Conclusion To summarise, in different skin colours and racial backgrounds, the density of melanocytes is near identical. The quantity and distribution of melanin is largely dependent upon for constitutive skin pigmentation. Less DNA damage occurs to melanocytes present in darker skin than those present in lighter skin. The activity of melanogenesis increases in darker skin in a more efficient manner than in lighter skin. The determination of constitutive skin pigmentation is achieved by: Melanoblasts migration during development Melanoblasts differentiation and survival to melanocytes Melanocyte density Melanosomal enzymes and their structural components expression and function Eumelanin and pheomelanin synthesis Melanosome transport to the dendrites Melanosomes being transferred into keratinocytes Melanin distribution in the skins suprabasal layers. MITF seems to respond to UV pretty quickly, with a response after 1 to 2 days. Some melanosomal proteins respond slower, such as tyrosinase, TRP-1 and DCT, with a response being elicited after about 1 week, where 3 weeks later an increase in the synthesis in melanin can be observed, whereas melanocyte density is increased around 4 to 5 weeks. Cyclic AMP causes the complex induction of intracellular processes which seem to be interconnected. The sub-pathway where PKA is activated, MITF is upregulated as is some of the enzymes involved in melanogenesis, causes melanogenesis stimulation. A cAMP activated pathway, through ERK activation inducing the degradation and phosphorylation of MITF, regulated melanogenesis negatively, where PKA is independent upon. The skins melanin distribution plays a key role in pigmentation that is visible. After around 1 week, the existing pigments migration towards the epidermal surface is increased, after which newly synthesis melanin restores the balance in the distribution of pigment around 4 to 5 weeks later. It is also apparent that when the distribution in the content of melanin undergoes minor changes, it can result in major changes in visible pigmentation, affecting constitutive pigmentation as well as facultative pigmentation or the responses to being exposed to UV. After reading through the literature to carry out this critical appraisal, it is evident that lots of studies have opposing and conflicting results as well as conclusions which may be incoherent, where the same group of authors may diverge from something which they have previously stated. This is most probably due to lots of variants when conducting these types of in vivo and in situ physiological studies. These variants most definitely include: UV source types How much dose amount and frequency that has been applied The sites which have been exposed and their locations The point in time which is assessed after being exposed to UV The history of the subjects, and whether they have been exposed to the same / higher levels of UV conducted in the experiments previously The capacity of an individual DNA repairing Very importantly, the racial and / or ethnic origin of the subjects. There are many areas which require clarification in field, which are definite area of potential future research. For example; Is melanocyte function affected eumelanin against pheomelanin production? As facultative pigmentation is increased, is there further protection against damage caused by UV? Does DNA repair have a role in reducing the skins long term damage? Also, photocarcinogenesis understanding needs to be enhanced, some of the parameters that are critical to it, and some strategies on how to reduce its risks. Research into which pathways participate in melanogenesis induced by UV and MSH still seems to be under way. Any advances could help in discovery of new potential ways of treating certain pigmentary disorders. The regulating mechanisms in the synthesis on melanin arent understood as clearly as required, where its been speculate that research into this may lead to topical melanogens discovery that can cause the production of melanin when UV irradiation is absent, which causes photo aging as well as some skin cancers. Further studies are necessary regarding the pigmentary role of ÃŽÂ ²-endorphin, which seems to be the forgotten melanocortin with regards to pigmentation. Similarly, the role of CRH in pigmentation also needs to be enhanced further. It is also shown that some hormones play a role in regulation of pigmentation including some oestrogens and androgens, which are areas that could used for further research to increase our understanding.

Sunday, October 13, 2019

The Body, Meaning and Symbols in Medical Anthropology Essay examples --

In the course of the study of medicine from an anthropological perspective, there are several themes which are repeatedly encountered. These include the body and its representation, meaning and a person’s response to that meaning, and finally, the symbolic images which construct and shape both meaning and the bodily representation. Each of these themes are addressed throughout medical anthropological texts, and are connected to and build on each other in a variety of ways. The body is the site of medicine, because the body is the site of all cultural practices. As Byron Good states, â€Å"medicine formulates the human body and disease in a culturally distinctive fashion†. (Good, 65) It is the cultural fashion of western medicine to objectify the body by constructing it in purely biochemical and molecular terms. As Shiehisa Kuriyama shows us in his work, this is the result of the historical development of Greek medicine and its intersection with the western scientific sentiment. Kuriyama says, â€Å"conceptions of the body owe as much to particular uses of the senses as to particular ‘ways of thinking.’† (Kuriyama, 12) He goes on to explain how a tradition of empiricism and a belief that â€Å"only [literal speech] can insure limpid understanding; [figurative speech] is profoundly unreliable† (Kuriyama, 75), informed the development of the western medical culture. With the obsession with clear and unambiguous language came a set of presuppositions, which, among other things, created a hierarchy of bodily representation. Kuriyama describes this in terms of western obsessions with musculature or the Chinese emphasis on how the skin looks. When the West undertook its various imperialistic projects across the globe this hierarchy of the... ...sm for a lack of modernity. Villagers were keenly aware of what the shaman meant not only to their own culture, but also what it meant to those in the transnational space, and their conception changes because of this. Thus we see how medical anthropology studies and provides analysis on the issues of the body, bodily perception, and the representation of the body, as well as meaning and symbolism. Also we see how medical anthropology takes these interpretations and uses them to critique the system’s practices. The biomedical system largely ignores the social aspects of illness, and this does a disservice to the suffering individual it seeks to restore. It emphasizes a biological reductionism which limits the care it can bring to the person it reconstructs as a patient, and in doing so, it discounts the multiple meanings medical symbols can hold for the patient.

Friday, October 11, 2019

Philosophy Educating Humanity? :: Philosophy Philosophical Papers

Philosophy Educating Humanity? ABSTRACT: Over two millennia of Western philosophy has not yet contributed much to the education of humanity. Philosophy has almost always been the exclusive domain of a small group of men. This elite character makes the assumption that philosophy could contribute to the education of human beings towards humanity — a humanity of human rights — improbable. If we want to educate human beings towards humanity, we will first have to teach them a sense of responsibility. The power of persuasion needed in order to teach such a sense of responsibility requires that we demonstrate our involvement in and co-responsibility for their concrete problems by presenting clear analyses of these problems and by setting a good example wherever possible. One of the most universal and concrete problems of life is the issue of procreation. As regards this issue, however, philosophers have failed miserably: they themselves have often exhibited irresponsible procreation and have, in fact, only recently begun to consider the issue a subject for philosophy. I will try to analyze when a decision to procreate or abort may be called responsible and whether and to what extent the applications of modern techniques such as in vitro fertilization are in line with our views of human rights. Two and a half thousand years of Western philosophy have not yet contributed much to the education of humanity. Philosophy has always been the almost exclusive domain of a small group of men, conversing in esoteric language on the most abstract of subjects, without being much concerned about the needs of the ordinary people around them. This elitism undermines the assumption that philosophy could contribute to the education of humanity as a whole, and it makes the assumption that it could contribute to the education of human beings towards humanity — a humanity of human rights — entirely improbable. If we want to educate human beings towards humanity we will first have to teach them a sense of responsibility: the awareness that each is responsible for his or her own actions and the consequences which can be expected to ensue, together with the awareness that a person’s rights and freedoms may not encroach upon the corresponding rights and freedoms of another. The power of persuasion needed in order to teach such a sense of responsibility requires that we demonstrate our involvement in and co-responsibility for their concrete problems, by presenting clear analyses of these problems and by setting a good example wherever possible.